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Each subunit binds, in addition to its two substrates (homocysteine and serine), heme (iron(II)-centered porphyrin), the role of which is not fully understood, and S-adenosyl-methionine (SAM), that acts as an allosteric activator

AMG133 (subcutaneous, every 4 weeks) is a monoclonal antibody that was designed to antagonise the GIP receptor and is also linked to two modified GLP-1 peptides that activate the GLP-1 receptor [58]

This result suggests that this pathway has increased importance under chloroquine treatment and could be targeted in combination therapies